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1

Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries

Parrish, Marcus C., Tan, Yuan Jin, Grimes, Kevin V., Mochly-Rosen, Daria

Journal:

Annual Review of Pharmacology

Year:

2019

Language:

english

File:

PDF, 1.01 MB

english, 2019

2

Glucose-6-Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus

Cunningham, Anna D., Hwang, Sunhee, Mochly-Rosen, Daria

Journal:

Clinics in Perinatology

Year:

2016

Language:

english

File:

PDF, 896 KB

english, 2016

3

Protein kinase C, an elusive therapeutic target?

Mochly-Rosen, Daria, Das, Kanad, Grimes, Kevin V.

Journal:

Nature Reviews Drug Discovery

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

4

Happy birthday protein kinase C: Past, present and future of a superfamily

Fiorenzo Battaini, Daria Mochly-Rosen

Journal:

Pharmacological Research

Year:

2007

Language:

english

File:

PDF, 846 KB

english, 2007

5

Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities

Kiyuna, Ligia Akemi, Albuquerque, Rudá Prestes e, Chen, Che-Hong, Mochly-Rosen, Daria, Ferreira, Julio Cesar Batista

Journal:

Free Radical Biology and Medicine

Year:

2018

Language:

english

File:

PDF, 1.04 MB

english, 2018

6

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

Joshi, Amit U., Minhas, Paras S., Liddelow, Shane A., Haileselassie, Bereketeab, Andreasson, Katrin I., Dorn, Gerald W., Mochly-Rosen, Daria

Journal:

Nature Neuroscience

Year:

2019

Language:

english

File:

PDF, 3.48 MB

english, 2019

7

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology

Joshi, Amit U., Van Wassenhove, Lauren D., Logas, Kelsey R., Minhas, Paras S., Andreasson, Katrin I., Weinberg, Kenneth I., Chen, Che-Hong, Mochly-Rosen, Daria

Journal:

Acta Neuropathologica Communications

Year:

2019

File:

PDF, 2.91 MB

2019

8

Rationally designed peptide regulators of protein kinase C

Eric N. Churchill, Nir Qvit, Daria Mochly-Rosen

Journal:

Trends in Endocrinology & Metabolism

Year:

2009

Language:

english

File:

PDF, 801 KB

english, 2009

9

PKC Isozymes in Chronic Cardiac Disease: Possible Therapeutic Targets?

Churchill, Eric, Budas, Grant, Vallentin, Alice, Koyanagi, Tomoyoshi, Mochly-Rosen, Daria

Journal:

Annual Review of Pharmacology

Year:

2008

Language:

english

File:

PDF, 645 KB

english, 2008

10

A Personalized Medicine Approach for Asian Americans with the Aldehyde Dehydrogenase 2*2 Variant

Gross, Eric R., Zambelli, Vanessa O., Small, Bryce A., Ferreira, Julio C.B., Chen, Che-Hong, Mochly-Rosen, Daria

Journal:

Annual Review of Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.08 MB

english, 2015

11

Interaction of monoclonal antibodies to torpedo acetylcholine receptor with the receptor of skeletal muscle

Miry C. Souroujon, Daria Mochly-Rosen, Dr. Adrienne S. Gordon, Dr. Sara Fuchs

Journal:

Year:

1983

Language:

english

File:

PDF, 722 KB

english, 1983

12

Cytotoxicity of pEGFP vector is due to residues encoded by multiple cloning site

Gerda Endemann, Deborah Schechtman, Daria Mochly-Rosen

Journal:

Analytical Biochemistry

Year:

2003

Language:

english

File:

PDF, 115 KB

english, 2003

13

RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling

Miller, Laura D, Lee, Kelly C, Mochly-Rosen, Daria, Cartwright, Christine A

Journal:

Year:

2004

Language:

english

File:

PDF, 213 KB

english, 2004

14

Modification of acetylcholine receptor: chemical and immunological characterization of polyalanyl acetylcholine receptor

Rebeca Tarrab-Hazdai, Yosefa Schmidt-Sole, Daria Mochly-Rosen, Sara Fuchs

Journal:

Year:

1980

Language:

english

File:

PDF, 351 KB

english, 1980

15

Isozyme-Specific Abnormalities of PKC in Thyroid Cancer: Evidence for Post-Transcriptional Changes in PKC Epsilon

Knauf, Jeffrey A., Ward, Laura S., Nikiforov, Yuri E., Nikiforova, Marina, Puxeddu, Efisio, Medvedovic, Mario, Liron, Tamar, Mochly-Rosen, Daria, Fagin, James A.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2002

Language:

english

File:

PDF, 356 KB

english, 2002

16

Peptidomimetic therapeutics: scientific approaches and opportunities

Qvit, Nir, Rubin, Samuel J.S., Urban, Travis J., Mochly-Rosen, Daria, Gross, Eric R.

Journal:

Drug Discovery Today

Year:

2016

Language:

english

File:

PDF, 419 KB

english, 2016

17

Anchoring proteins for protein kinase C: a means for isozyme selectivity

Mochly-Rosen, Daria, Gordon, Adrienne S.

Journal:

The FASEB Journal

Year:

1998

Language:

english

File:

PDF, 2.65 MB

english, 1998

18

Involvement of a p38 Mitogen-activated Protein Kinase Phosphatase in Protecting Neonatal Rat Cardiac Myocytes from Ischemia

Katrina Mackay, Daria Mochly-Rosen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2000

Language:

english

File:

PDF, 99 KB

english, 2000

19

Mast Cells, the Allergic Responders, a Target of Heart Failure Therapy?

Suresh S. Palaniyandi, Kenichi Watanabe, Daria Mochly-Rosen

Journal:

Journal of Cardiac Failure

Year:

2008

Language:

english

File:

PDF, 63 KB

english, 2008

20

Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury

Grant R. Budas, Eric N. Churchill, Daria Mochly-Rosen

Journal:

Pharmacological Research

Year:

2007

Language:

english

File:

PDF, 713 KB

english, 2007

21

Cardioprotection caused by ischemic preconditioning or by an alpha 1-adrenergic receptor agonist is blocked in hearts from epsilon protein kinase C knockout mice

Hui-zhong Zhou, Joel S. Karliner, Peili Zhu, Daria Mochly-Rosen, Robert O. Messing, Mary O. Gray

Journal:

Journal of the American College of Cardiology

Year:

2002

Language:

english

File:

PDF, 169 KB

english, 2002

22

The Role of Adenosine and Adenosine Transport in Ethanol-Induced Cellular Tolerance and Dependence : Possible Biologic and Genetic Markers of Alcoholism

IVAN DIAMOND, LAURA NAGY, DARIA MOCHLY-ROSEN, ADRIENNE GORDON

Journal:

Annals of the New York Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 719 KB

english, 1991

23

The many hats of protein kinase Cδ: one enzyme with many functions

Qvit, Nir, Mochly-Rosen, Daria

Journal:

Biochemical Society Transactions

Year:

2014

Language:

english

File:

PDF, 299 KB

english, 2014

24

Preserved coronary endothelial function by inhibition of δ protein kinase C in a porcine acute myocardial infarction model

Hideaki Kaneda, Fumiaki Ikeno, Koichi Inagaki, Daria Mochly-Rosen

Journal:

International Journal of Cardiology

Year:

2009

Language:

english

File:

PDF, 257 KB

english, 2009

25

Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells

Qinxue Ding, Hong Chai, Nausheen Mahmood, Jerry Tsao, Daria Mochly-Rosen, Wei Zhou

Journal:

Journal of Vascular Surgery

Year:

2011

Language:

english

File:

PDF, 1.09 MB

english, 2011

26

Cell-specific role for ε- and βI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury

Jian Wang, Rachel Bright, Daria Mochly-Rosen, Rona G. Giffard

Journal:

Neuropharmacology

Year:

2004

Language:

english

File:

PDF, 325 KB

english, 2004

27

21 Enhanced protection of the ischemic heart by combined treatment with δPKC inhibitor and εPKC activator

Koichi Inagaki, Daria Mochly-Rosen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

28

Highly specific modulators of protein kinase C localization: applications to heart failure

Nir Qvit, Daria Mochly-Rosen

Journal:

Drug Discovery Today: Disease Mechanisms

Year:

2010

Language:

english

File:

PDF, 383 KB

english, 2010

29

Antigenic specificity of acetylcholine receptor in developing muscle: Studies with monoclonal antibodies

Miry C. Souroujon, Sergio Pizzighella, Daria Mochly-Rosen, Sara Fuchs

Journal:

Journal of Neuroimmunology

Year:

1985

Language:

english

File:

PDF, 415 KB

english, 1985

30

Aldehyde Dehydrogenase 2 in Aplastic Anemia, Fanconi Anemia and Hematopoietic Stem Cells

Van Wassenhove, Lauren D., Mochly-Rosen, Daria, Weinberg, Kenneth I.

Journal:

Molecular Genetics and Metabolism

Year:

2016

Language:

english

File:

PDF, 885 KB

english, 2016

31

Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics

Qvit, Nir, Kornfeld, Opher S., Mochly-Rosen, Daria

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 3.45 MB

english, 2016

32

Peptides and peptidomimetics as regulators of protein–protein interactions

Cunningham, Anna D, Qvit, Nir, Mochly-Rosen, Daria

Journal:

Current Opinion in Structural Biology

Year:

2017

Language:

english

File:

PDF, 953 KB

english, 2017

33

The Effect of Ethanol Consumption on Composition and Morphology of Femur Cortical Bone in Wild-Type and ALDH2*2-Homozygous Mice

Malkovskiy, Andrey V., Van Wassenhove, Lauren D., Goltsev, Yury, Osei-Sarfo, Kwame, Chen, Che-Hong, Efron, Bradley, Gudas, Lorraine J., Mochly-Rosen, Daria, Rajadas, Jayakumar

Journal:

Calcified Tissue International

Year:

2020

File:

PDF, 1.67 MB

2020

34

Localization, Anchoring, and Functions of Protein Kinase C Isozymes in the Heart

Katrina Mackay, Daria Mochly-Rosen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2001

Language:

english

File:

PDF, 105 KB

english, 2001

35

22 A role for delta PKC in cardiac reperfusion injury in vivo

Leon Chen, Koichi Ingaki, Fumiaki Ikeno, Felix Lee, Paul Yock, Daria Mochly-Rosen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

36

Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C

Gross, Eric R., Hsu, Anna K., Urban, Travis J., Mochly-Rosen, Daria, Gross, Garrett J.

Journal:

Basic Research in Cardiology

Year:

2013

Language:

english

File:

PDF, 807 KB

english, 2013

37

Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo

Chen, Che-Hong, Cruz, Leslie A., Mochly-Rosen, Daria

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1000 KB

english, 2015

38

Molecular transporters for peptides: delivery of a cardioprotective ϵPKC agonist peptide into cells and intact ischemic heart using a transport system, R7

Leon Chen, Lee R Wright, Che-Hong Chen, Steven F Oliver, Paul A Wender, Daria Mochly-Rosen

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 355 KB

english, 2001

39

A81. Ischemic preconditioining decreases delta PKC levels resulting in diminished translocation during reperfusion

Eric N. Churchill, Daria Mochly-Rosen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2006

Language:

english

File:

PDF, 53 KB

english, 2006

40

Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of ɛPKC and activation of aldehyde dehydrogenase 2

Eric N. Churchill, Marie-Hélène Disatnik, Daria Mochly-Rosen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2009

Language:

english

File:

PDF, 730 KB

english, 2009

41

23 Delta PKC in cerebral ischemic and reperfusion injury in vivo

Rachel Bright, Jeffrey M. Dembner, Midori A. Yenari, Gary K. Steinberg, Daria Mochly-Rosen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

42

Translational medicine: mitigating risks for investigators

Mann, Douglas L., Mochly-Rosen, Daria

Journal:

Nature Reviews Drug Discovery

Year:

2013

Language:

english

File:

PDF, 89 KB

english, 2013

43

The challenge in translating basic research discoveries to treatment of Huntington disease

Mochly-Rosen, Daria, Disatnik, Marie-Helene, Qi, Xin

Journal:

Year:

2014

Language:

english

File:

PDF, 1.53 MB

english, 2014

44

Alcohol consumption and vascular disease: other points to consider

Chen, Che-Hong, Ferreira, Julio C B, Mochly-Rosen, Daria, Gross, Eric R

Journal:

Lancet (London, England)

Year:

2019

Language:

english

File:

PDF, 88 KB

english, 2019

45

A75. Nanoparticles: Novel cardioprotective devices that utilize a preconditioning-like mechanism

Eric N. Churchill, Rachel Bright, Corinne Bright, Kam Leong, Luke Szweda, Daria Mochly-Rosen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2006

Language:

english

File:

PDF, 64 KB

english, 2006

46

1051-131 Combined treatment with epsilon protein kinase C activator and delta protein kinase C inhibitor ameliorates ischemia reperfusion injury with prolonged ischemia in rat cardiac allografts

Masashi Tanaka, Raya D Terry, G.Kimia Mokhtari, E.Grant Hoyt, Tomoyoshi Koyanagi, Koichi Inagaki, Theo Kofidis, Daria Mochly-Rosen, Robert C Robbins

Journal:

Journal of the American College of Cardiology

Year:

2004

Language:

english

File:

PDF, 62 KB

english, 2004

47

PKCε activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting

Monti, Martina, Donnini, Sandra, Morbidelli, Lucia, Giachetti, Antonio, Mochly-Rosen, Daria, Mignatti, Paolo, Ziche, Marina

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2013

Language:

english

File:

PDF, 1.65 MB

english, 2013

48

Developmental expression of protein kinase C subspecies in rat brain-pituitary axis

Garcia-Navarro, Socorro, Marantz, Yael, Eyal, Rami, Kalina, Moshe, Disatnik, Marie-Helene, Mochly-Rosen, Daria, Ben-Menahem, David, Reiss, Nachum, Naor, Zvi

Journal:

Molecular and Cellular Endocrinology

Year:

1994

Language:

english

File:

PDF, 1.09 MB

english, 1994

49

The Identification and Purification of a Mammalian-Like Protein Kinase C in the Yeast Saccharomyces cerevisiae

Amos J. Simon, Yoram Milner, Stephen P. Saville, Arik Dvir, Daria Mochly-Rosen and Elisha Orr

Journal:

Proceedings Biological Sciences

Year:

1991

Language:

english

File:

PDF, 1.49 MB

english, 1991

50

Phorbol Myristate Acetate-Mediated Stimulation of Transcytosis and Apical Recycling in MDCK Cells

Michael H. Cardone, Bradley L. Smith, Wenxia Song, Daria Mochly-Rosen and Keith E. Mostov

Journal:

The Journal of Cell Biology

Year:

1994

Language:

english

File:

PDF, 1.07 MB

english, 1994

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